5IS5

Discovery and Pharmacological Characterization of Novel Quinazoline-based PI3K delta-selective Inhibitors

Summary for 5IS5

Entry DOI	10.2210/pdb5is5/pdb
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 5-{4-[3-(4-acetylpiperazine-1-carbonyl)phenyl]quinazolin-6-yl}-2-methoxypyridine-3-carbonitrile (3 entities in total)
Functional Keywords	phosphoinositide 3-kinase, isoform-sepcific inhibitors, transferase
Biological source	Mus musculus (Mouse)
Total number of polymer chains	1
Total formula weight	120491.99
Authors	Gutmann, S.,Rummel, G.,Shrestha, B. (deposition date: 2016-03-15, release date: 2016-08-10, Last modification date: 2024-01-10)
Primary citation	Hoegenauer, K.,Soldermann, N.,Stauffer, F.,Furet, P.,Graveleau, N.,Smith, A.B.,Hebach, C.,Hollingworth, G.J.,Lewis, I.,Gutmann, S.,Rummel, G.,Knapp, M.,Wolf, R.M.,Blanz, J.,Feifel, R.,Burkhart, C.,Zecri, F. Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors. Acs Med.Chem.Lett., 7:762-767, 2016 Cited by PubMed: 27563400 DOI: 10.1021/acsmedchemlett.6b00119 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation