5IPA

Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with (E)-3-(furan-3-yl)-1-(pyrrolidin-1-yl)prop-2-en-1-one at 1.78A resolution

Summary for 5IPA

Entry DOI	10.2210/pdb5ipa/pdb
Descriptor	TetR-family transcriptional regulatory repressor protein, (2E)-3-(furan-3-yl)-1-(pyrrolidin-1-yl)prop-2-en-1-one (3 entities in total)
Functional Keywords	ethr, transcription, represor, boosting effect
Biological source	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Total number of polymer chains	1
Total formula weight	24355.38
Authors	Blaszczyk, M.,Surade, S.,Nikiforov, P.O.,Abell, C.,Blundell, T.L. (deposition date: 2016-03-09, release date: 2017-03-29, Last modification date: 2024-01-10)
Primary citation	Nikiforov, P.O.,Blaszczyk, M.,Surade, S.,Boshoff, H.I.,Sajid, A.,Delorme, V.,Deboosere, N.,Brodin, P.,Baulard, A.R.,Barry, C.E.,Blundell, T.L.,Abell, C. Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays. ACS Chem. Biol., 12:1390-1396, 2017 Cited by PubMed: 28314097 DOI: 10.1021/acschembio.7b00091 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.78 Å)

Structure validation