5IGN

Crystal structure of human BRD9 bromodomain in complex with LP99 chemical probe

Summary for 5IGN

• Entry DOI: 10.2210/pdb5ign/pdb
• Descriptor: Bromodomain-containing protein 9, N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3-yl]-2-methylpropane-1-sulfonamide (3 entities in total)
• Functional Keywords: lysine-acetylated histone binding, chromatin regulator, transcription, structural genomics, structural genomics consortium, sgc
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 29531.63

Authors

Tallant, C.,Clark, P.G.K.,Vieira, L.C.C.,Newman, J.A.,Krojer, T.,Nunez-Alonso, G.,Picaud, S.,Fedorov, O.,Dixon, D.J.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Brennan, P.E.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2016-02-28, release date: 2016-03-30, Last modification date: 2024-01-10)

• Primary citation: Tallant, C.,Clark, P.G.K.,Vieira, L.C.C.,Krojer, T.,Nunez-Alonso, G.,Picaud, S.,Fedorov, O.,Dixon, D.J.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Brennan, P.E.,Knapp, S.; Crystal structure of BRD9 bromodomain in complex with LP99 chemical probe; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)