5IFS

Quantitative interaction mapping reveals an extended ubiquitin regulatory domain in ASPL that disrupts functional p97 hexamers and induces cell death

5IFS の概要

• エントリーDOI: 10.2210/pdb5ifs/pdb
• 分子名称: Tether containing UBX domain for GLUT4, Transitional endoplasmic reticulum ATPase, ADENOSINE-5'-DIPHOSPHATE, ... (8 entities in total)
• 機能のキーワード: aspl, p97, disassembly, eubx, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Endomembrane system ; Peripheral membrane protein : Q9BZE9; Cytoplasm, cytosol: P55072
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 161196.42

構造登録者

Roske, Y.,Arumughan, A.,Heinemann, U.,Wanker, E. (登録日: 2016-02-26, 公開日: 2016-10-26, 最終更新日: 2024-01-10)

• 主引用文献: Arumughan, A.,Roske, Y.,Barth, C.,Forero, L.L.,Bravo-Rodriguez, K.,Redel, A.,Kostova, S.,McShane, E.,Opitz, R.,Faelber, K.,Rau, K.,Mielke, T.,Daumke, O.,Selbach, M.,Sanchez-Garcia, E.,Rocks, O.,Panakova, D.,Heinemann, U.,Wanker, E.E.; Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.; Nat Commun, 7:13047-13047, 2016; PubMed: 27762274; DOI: 10.1038/ncomms13047

実験手法

X-RAY DIFFRACTION (2.46 Å)