5IA0

Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with alisertib (MLN8237)

Summary for 5IA0

• Entry DOI: 10.2210/pdb5ia0/pdb
• Descriptor: Ephrin type-A receptor 2, alisertib, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: transferase, tyrosine-protein kinase, receptor, atp-binding
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 106186.65

Authors

Kudlinzki, D.,Linhard, V.L.,Gande, S.L.,Sreeramulu, S.,Saxena, K.,Heinzlmeir, S.,Medard, G.,Kuester, B.,Schwalbe, H. (deposition date: 2016-02-21, release date: 2016-11-09, Last modification date: 2024-01-10)

• Primary citation: Heinzlmeir, S.,Kudlinzki, D.,Sreeramulu, S.,Klaeger, S.,Gande, S.L.,Linhard, V.,Wilhelm, M.,Qiao, H.,Helm, D.,Ruprecht, B.,Saxena, K.,Medard, G.,Schwalbe, H.,Kuster, B.; Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.; ACS Chem. Biol., 11:3400-3411, 2016; PubMed: 27768280; DOI: 10.1021/acschembio.6b00709

Experimental method

X-RAY DIFFRACTION (1.948 Å)