5HZN

Structure of NVP-AEW541 in complex with IGF-1R kinase

Summary for 5HZN

• Entry DOI: 10.2210/pdb5hzn/pdb
• Descriptor: Insulin-like growth factor 1 receptor, 7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total)
• Functional Keywords: inhibitor, kinase, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane ; Single-pass type I membrane protein : P08069
• Total number of polymer chains: 8
• Total formula weight: 282324.63

Authors

Cowan-Jacob, S.W. (deposition date: 2016-02-02, release date: 2016-04-06, Last modification date: 2016-12-21)

• Primary citation: Stauffer, F.,Cowan-Jacob, S.W.,Scheufler, C.,Furet, P.; Identification of a 5-[3-phenyl-(2-cyclic-ether)-methylether]-4-aminopyrrolo[2,3-d]pyrimidine series of IGF-1R inhibitors.; Bioorg.Med.Chem.Lett., 26:2065-2067, 2016; PubMed: 26951750; DOI: 10.1016/j.bmcl.2016.02.074

Experimental method

X-RAY DIFFRACTION (2.2 Å)