5HZN
Structure of NVP-AEW541 in complex with IGF-1R kinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Insulin-like growth factor 1 receptor | polymer | 304 | 34607.8 | 8 | UniProt (P08069) Pfam (PF07714) | Homo sapiens (Human) | Insulin-like growth factor I receptor,IGF-I receptor |
| 2 | AA, I, L, N, Q... (H, A, B, C, D...) | 7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine | non-polymer | 439.6 | 8 | Chemie (66A) | |||
| 3 | BA, J, M, O, R... (H, A, B, C, D...) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 8 | Chemie (MES) | |||
| 4 | K, P, U, Z (A, C, E, G) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 5 | CA, DA, EA, FA, GA... (A, B, C, D, E...) | water | water | 18.0 | 551 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 980 - 1283 (UniProt: P08069)
| PDB | External Database | Details |
|---|---|---|
| Ala 1094 | Glu 1097 | engineered mutation |
| Ala 1096 | Glu 1099 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 276862.1 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 5462.6 | |
| All* | Total formula weight | 282324.6 |
