5HYN
Structure of Human Polycomb Repressive Complex 2 (PRC2) with oncogenic histone H3K27M peptide
Summary for 5HYN
Entry DOI | 10.2210/pdb5hyn/pdb |
Descriptor | Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, Polycomb protein SUZ12, ... (7 entities in total) |
Functional Keywords | chromatin modification complex, transferase |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : Q15910 O75530 Q15022 |
Total number of polymer chains | 20 |
Total formula weight | 586815.22 |
Authors | Zhang, Y.,Justin, N.,Wilson, J.R.,Gamblin, S.J. (deposition date: 2016-02-01, release date: 2016-05-11) |
Primary citation | Justin, N.,Zhang, Y.,Tarricone, C.,Martin, S.R.,Chen, S.,Underwood, E.,De Marco, V.,Haire, L.F.,Walker, P.A.,Reinberg, D.,Wilson, J.R.,Gamblin, S.J. Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2. Nat Commun, 7:11316-11316, 2016 Cited by PubMed: 27121947DOI: 10.1038/ncomms11316 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
Download full validation report