5HYN

Structure of Human Polycomb Repressive Complex 2 (PRC2) with oncogenic histone H3K27M peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0000792	cellular_component	heterochromatin
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
A	0001222	molecular_function	transcription corepressor binding
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003714	molecular_function	transcription corepressor activity
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005677	cellular_component	chromatin silencing complex
A	0005694	cellular_component	chromosome
A	0005721	cellular_component	pericentric heterochromatin
A	0006325	biological_process	chromatin organization
A	0006338	biological_process	chromatin remodeling
A	0006351	biological_process	DNA-templated transcription
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008168	molecular_function	methyltransferase activity
A	0008284	biological_process	positive regulation of cell population proliferation
A	0010629	biological_process	negative regulation of gene expression
A	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
A	0016279	molecular_function	protein-lysine N-methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0021766	biological_process	hippocampus development
A	0030183	biological_process	B cell differentiation
A	0030335	biological_process	positive regulation of cell migration
A	0031048	biological_process	regulatory ncRNA-mediated heterochromatin formation
A	0031490	molecular_function	chromatin DNA binding
A	0031491	molecular_function	nucleosome binding
A	0031507	biological_process	heterochromatin formation
A	0031509	biological_process	subtelomeric heterochromatin formation
A	0031519	cellular_component	PcG protein complex
A	0032259	biological_process	methylation
A	0032355	biological_process	response to estradiol
A	0035098	cellular_component	ESC/E(Z) complex
A	0042054	molecular_function	histone methyltransferase activity
A	0042393	molecular_function	histone binding
A	0042752	biological_process	regulation of circadian rhythm
A	0043021	molecular_function	ribonucleoprotein complex binding
A	0043406	biological_process	positive regulation of MAP kinase activity
A	0043547	biological_process	positive regulation of GTPase activity
A	0043565	molecular_function	sequence-specific DNA binding
A	0045120	cellular_component	pronucleus
A	0045202	cellular_component	synapse
A	0045814	biological_process	negative regulation of gene expression, epigenetic
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046976	molecular_function	histone H3K27 methyltransferase activity
A	0048387	biological_process	negative regulation of retinoic acid receptor signaling pathway
A	0048468	biological_process	cell development
A	0048511	biological_process	rhythmic process
A	0051932	biological_process	synaptic transmission, GABAergic
A	0070878	molecular_function	primary miRNA binding
A	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
A	0090183	biological_process	regulation of kidney development
A	0106222	molecular_function	lncRNA binding
A	0140718	biological_process	facultative heterochromatin formation
A	0140938	molecular_function	histone H3 methyltransferase activity
A	0140951	molecular_function	histone H3K27 trimethyltransferase activity
A	1900006	biological_process	positive regulation of dendrite development
A	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
A	1902808	biological_process	positive regulation of cell cycle G1/S phase transition
A	1990841	molecular_function	promoter-specific chromatin binding
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0000781	cellular_component	chromosome, telomeric region
F	0000785	cellular_component	chromatin
F	0000792	cellular_component	heterochromatin
F	0000976	molecular_function	transcription cis-regulatory region binding
F	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
F	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
F	0001222	molecular_function	transcription corepressor binding
F	0003677	molecular_function	DNA binding
F	0003682	molecular_function	chromatin binding
F	0003714	molecular_function	transcription corepressor activity
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005677	cellular_component	chromatin silencing complex
F	0005694	cellular_component	chromosome
F	0005721	cellular_component	pericentric heterochromatin
F	0006325	biological_process	chromatin organization
F	0006338	biological_process	chromatin remodeling
F	0006351	biological_process	DNA-templated transcription
F	0006355	biological_process	regulation of DNA-templated transcription
F	0008168	molecular_function	methyltransferase activity
F	0008284	biological_process	positive regulation of cell population proliferation
F	0010629	biological_process	negative regulation of gene expression
F	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
F	0016279	molecular_function	protein-lysine N-methyltransferase activity
F	0016740	molecular_function	transferase activity
F	0021766	biological_process	hippocampus development
F	0030183	biological_process	B cell differentiation
F	0030335	biological_process	positive regulation of cell migration
F	0031048	biological_process	regulatory ncRNA-mediated heterochromatin formation
F	0031490	molecular_function	chromatin DNA binding
F	0031491	molecular_function	nucleosome binding
F	0031507	biological_process	heterochromatin formation
F	0031509	biological_process	subtelomeric heterochromatin formation
F	0031519	cellular_component	PcG protein complex
F	0032259	biological_process	methylation
F	0032355	biological_process	response to estradiol
F	0035098	cellular_component	ESC/E(Z) complex
F	0042054	molecular_function	histone methyltransferase activity
F	0042393	molecular_function	histone binding
F	0042752	biological_process	regulation of circadian rhythm
F	0043021	molecular_function	ribonucleoprotein complex binding
F	0043406	biological_process	positive regulation of MAP kinase activity
F	0043547	biological_process	positive regulation of GTPase activity
F	0043565	molecular_function	sequence-specific DNA binding
F	0045120	cellular_component	pronucleus
F	0045202	cellular_component	synapse
F	0045814	biological_process	negative regulation of gene expression, epigenetic
F	0045892	biological_process	negative regulation of DNA-templated transcription
F	0046976	molecular_function	histone H3K27 methyltransferase activity
F	0048387	biological_process	negative regulation of retinoic acid receptor signaling pathway
F	0048468	biological_process	cell development
F	0048511	biological_process	rhythmic process
F	0051932	biological_process	synaptic transmission, GABAergic
F	0070878	molecular_function	primary miRNA binding
F	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
F	0090183	biological_process	regulation of kidney development
F	0106222	molecular_function	lncRNA binding
F	0140718	biological_process	facultative heterochromatin formation
F	0140938	molecular_function	histone H3 methyltransferase activity
F	0140951	molecular_function	histone H3K27 trimethyltransferase activity
F	1900006	biological_process	positive regulation of dendrite development
F	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
F	1902808	biological_process	positive regulation of cell cycle G1/S phase transition
F	1990841	molecular_function	promoter-specific chromatin binding
K	0000122	biological_process	negative regulation of transcription by RNA polymerase II
K	0000781	cellular_component	chromosome, telomeric region
K	0000785	cellular_component	chromatin
K	0000792	cellular_component	heterochromatin
K	0000976	molecular_function	transcription cis-regulatory region binding
K	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
K	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
K	0001222	molecular_function	transcription corepressor binding
K	0003677	molecular_function	DNA binding
K	0003682	molecular_function	chromatin binding
K	0003714	molecular_function	transcription corepressor activity
K	0003723	molecular_function	RNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005677	cellular_component	chromatin silencing complex
K	0005694	cellular_component	chromosome
K	0005721	cellular_component	pericentric heterochromatin
K	0006325	biological_process	chromatin organization
K	0006338	biological_process	chromatin remodeling
K	0006351	biological_process	DNA-templated transcription
K	0006355	biological_process	regulation of DNA-templated transcription
K	0008168	molecular_function	methyltransferase activity
K	0008284	biological_process	positive regulation of cell population proliferation
K	0010629	biological_process	negative regulation of gene expression
K	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
K	0016279	molecular_function	protein-lysine N-methyltransferase activity
K	0016740	molecular_function	transferase activity
K	0021766	biological_process	hippocampus development
K	0030183	biological_process	B cell differentiation
K	0030335	biological_process	positive regulation of cell migration
K	0031048	biological_process	regulatory ncRNA-mediated heterochromatin formation
K	0031490	molecular_function	chromatin DNA binding
K	0031491	molecular_function	nucleosome binding
K	0031507	biological_process	heterochromatin formation
K	0031509	biological_process	subtelomeric heterochromatin formation
K	0031519	cellular_component	PcG protein complex
K	0032259	biological_process	methylation
K	0032355	biological_process	response to estradiol
K	0035098	cellular_component	ESC/E(Z) complex
K	0042054	molecular_function	histone methyltransferase activity
K	0042393	molecular_function	histone binding
K	0042752	biological_process	regulation of circadian rhythm
K	0043021	molecular_function	ribonucleoprotein complex binding
K	0043406	biological_process	positive regulation of MAP kinase activity
K	0043547	biological_process	positive regulation of GTPase activity
K	0043565	molecular_function	sequence-specific DNA binding
K	0045120	cellular_component	pronucleus
K	0045202	cellular_component	synapse
K	0045814	biological_process	negative regulation of gene expression, epigenetic
K	0045892	biological_process	negative regulation of DNA-templated transcription
K	0046976	molecular_function	histone H3K27 methyltransferase activity
K	0048387	biological_process	negative regulation of retinoic acid receptor signaling pathway
K	0048468	biological_process	cell development
K	0048511	biological_process	rhythmic process
K	0051932	biological_process	synaptic transmission, GABAergic
K	0070878	molecular_function	primary miRNA binding
K	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
K	0090183	biological_process	regulation of kidney development
K	0106222	molecular_function	lncRNA binding
K	0140718	biological_process	facultative heterochromatin formation
K	0140938	molecular_function	histone H3 methyltransferase activity
K	0140951	molecular_function	histone H3K27 trimethyltransferase activity
K	1900006	biological_process	positive regulation of dendrite development
K	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
K	1902808	biological_process	positive regulation of cell cycle G1/S phase transition
K	1990841	molecular_function	promoter-specific chromatin binding
Q	0000122	biological_process	negative regulation of transcription by RNA polymerase II
Q	0000781	cellular_component	chromosome, telomeric region
Q	0000785	cellular_component	chromatin
Q	0000792	cellular_component	heterochromatin
Q	0000976	molecular_function	transcription cis-regulatory region binding
Q	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
Q	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
Q	0001222	molecular_function	transcription corepressor binding
Q	0003677	molecular_function	DNA binding
Q	0003682	molecular_function	chromatin binding
Q	0003714	molecular_function	transcription corepressor activity
Q	0003723	molecular_function	RNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005677	cellular_component	chromatin silencing complex
Q	0005694	cellular_component	chromosome
Q	0005721	cellular_component	pericentric heterochromatin
Q	0006325	biological_process	chromatin organization
Q	0006338	biological_process	chromatin remodeling
Q	0006351	biological_process	DNA-templated transcription
Q	0006355	biological_process	regulation of DNA-templated transcription
Q	0008168	molecular_function	methyltransferase activity
Q	0008284	biological_process	positive regulation of cell population proliferation
Q	0010629	biological_process	negative regulation of gene expression
Q	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
Q	0016279	molecular_function	protein-lysine N-methyltransferase activity
Q	0016740	molecular_function	transferase activity
Q	0021766	biological_process	hippocampus development
Q	0030183	biological_process	B cell differentiation
Q	0030335	biological_process	positive regulation of cell migration
Q	0031048	biological_process	regulatory ncRNA-mediated heterochromatin formation
Q	0031490	molecular_function	chromatin DNA binding
Q	0031491	molecular_function	nucleosome binding
Q	0031507	biological_process	heterochromatin formation
Q	0031509	biological_process	subtelomeric heterochromatin formation
Q	0031519	cellular_component	PcG protein complex
Q	0032259	biological_process	methylation
Q	0032355	biological_process	response to estradiol
Q	0035098	cellular_component	ESC/E(Z) complex
Q	0042054	molecular_function	histone methyltransferase activity
Q	0042393	molecular_function	histone binding
Q	0042752	biological_process	regulation of circadian rhythm
Q	0043021	molecular_function	ribonucleoprotein complex binding
Q	0043406	biological_process	positive regulation of MAP kinase activity
Q	0043547	biological_process	positive regulation of GTPase activity
Q	0043565	molecular_function	sequence-specific DNA binding
Q	0045120	cellular_component	pronucleus
Q	0045202	cellular_component	synapse
Q	0045814	biological_process	negative regulation of gene expression, epigenetic
Q	0045892	biological_process	negative regulation of DNA-templated transcription
Q	0046976	molecular_function	histone H3K27 methyltransferase activity
Q	0048387	biological_process	negative regulation of retinoic acid receptor signaling pathway
Q	0048468	biological_process	cell development
Q	0048511	biological_process	rhythmic process
Q	0051932	biological_process	synaptic transmission, GABAergic
Q	0070878	molecular_function	primary miRNA binding
Q	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
Q	0090183	biological_process	regulation of kidney development
Q	0106222	molecular_function	lncRNA binding
Q	0140718	biological_process	facultative heterochromatin formation
Q	0140938	molecular_function	histone H3 methyltransferase activity
Q	0140951	molecular_function	histone H3K27 trimethyltransferase activity
Q	1900006	biological_process	positive regulation of dendrite development
Q	1900016	biological_process	negative regulation of cytokine production involved in inflammatory response
Q	1902808	biological_process	positive regulation of cell cycle G1/S phase transition
Q	1990841	molecular_function	promoter-specific chromatin binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1001

Chain	Residue
A	CYS286
A	CYS289
A	CYS294
A	HIS297

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1002

Chain	Residue
A	CYS320
A	CYS324
A	CYS452
A	CYS463

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 1003

Chain	Residue
A	CYS543
A	CYS549
A	CYS553
A	CYS530

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN A 1004

Chain	Residue
A	CYS523
A	HIS525
A	CYS530
A	CYS534

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN A 1005

Chain	Residue
A	CYS523
A	CYS536
A	CYS543
A	CYS547

---

site_id	AC6
Number of Residues	7
Details	binding site for residue ZN A 1006

Chain	Residue
A	CYS560
A	CYS566
A	CYS580
A	CYS588
A	CYS601
A	ZN1007
A	ZN1008

---

site_id	AC7
Number of Residues	6
Details	binding site for residue ZN A 1007

Chain	Residue
A	CYS560
A	CYS573
A	CYS580
A	CYS585
A	ZN1006
A	ZN1008

---

site_id	AC8
Number of Residues	6
Details	binding site for residue ZN A 1008

Chain	Residue
A	CYS560
A	CYS562
A	CYS566
A	CYS571
A	ZN1006
A	ZN1007

---

site_id	AC9
Number of Residues	15
Details	binding site for residue SAH A 1009

Chain	Residue
A	VAL621
A	ALA622
A	GLY623
A	TRP624
A	MET662
A	CYS663
A	SER664
A	PHE665
A	PHE686
A	ALA687
A	ASN688
A	HIS689
A	TYR726
A	LEU734
A	TYR736

---

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN F 1001

Chain	Residue
F	CYS286
F	CYS289
F	CYS294
F	HIS297

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN F 1002

Chain	Residue
F	CYS320
F	CYS324
F	CYS452
F	CYS463

---

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN F 1003

Chain	Residue
F	CYS530
F	CYS543
F	CYS549
F	CYS553

---

site_id	AD4
Number of Residues	4
Details	binding site for residue ZN F 1004

Chain	Residue
F	CYS523
F	HIS525
F	CYS530
F	CYS534

---

site_id	AD5
Number of Residues	4
Details	binding site for residue ZN F 1005

Chain	Residue
F	CYS523
F	CYS536
F	CYS543
F	CYS547

---

site_id	AD6
Number of Residues	4
Details	binding site for residue ZN F 1006

Chain	Residue
F	CYS566
F	CYS580
F	CYS588
F	CYS601

---

site_id	AD7
Number of Residues	5
Details	binding site for residue ZN F 1007

Chain	Residue
F	CYS560
F	CYS573
F	CYS580
F	CYS585
F	ZN1008

---

site_id	AD8
Number of Residues	5
Details	binding site for residue ZN F 1008

Chain	Residue
F	CYS560
F	CYS562
F	CYS566
F	CYS571
F	ZN1007

---

site_id	AD9
Number of Residues	15
Details	binding site for residue SAH F 1009

Chain	Residue
F	TYR726
F	ALA733
F	LEU734
F	TYR736
F	VAL621
F	ALA622
F	GLY623
F	TRP624
F	MET662
F	CYS663
F	SER664
F	PHE665
F	PHE686
F	ASN688
F	HIS689

---

site_id	AE1
Number of Residues	4
Details	binding site for residue ZN K 1001

Chain	Residue
K	CYS286
K	CYS289
K	CYS294
K	HIS297

---

site_id	AE2
Number of Residues	4
Details	binding site for residue ZN K 1002

Chain	Residue
K	CYS320
K	CYS324
K	CYS452
K	CYS463

---

site_id	AE3
Number of Residues	4
Details	binding site for residue ZN K 1003

Chain	Residue
K	CYS530
K	CYS543
K	CYS549
K	CYS553

---

site_id	AE4
Number of Residues	4
Details	binding site for residue ZN K 1004

Chain	Residue
K	CYS523
K	HIS525
K	CYS530
K	CYS534

---

site_id	AE5
Number of Residues	4
Details	binding site for residue ZN K 1005

Chain	Residue
K	CYS523
K	CYS536
K	CYS543
K	CYS547

---

site_id	AE6
Number of Residues	4
Details	binding site for residue ZN K 1006

Chain	Residue
K	CYS566
K	CYS580
K	CYS588
K	CYS601

---

site_id	AE7
Number of Residues	5
Details	binding site for residue ZN K 1007

Chain	Residue
K	CYS560
K	CYS573
K	CYS580
K	CYS585
K	ZN1008

---

site_id	AE8
Number of Residues	5
Details	binding site for residue ZN K 1008

Chain	Residue
K	CYS560
K	CYS562
K	CYS566
K	CYS571
K	ZN1007

---

site_id	AE9
Number of Residues	13
Details	binding site for residue SAH K 1009

Chain	Residue
K	VAL621
K	ALA622
K	GLY623
K	TRP624
K	MET662
K	CYS663
K	SER664
K	PHE665
K	ARG685
K	PHE686
K	ASN688
K	HIS689
K	TYR726

---

site_id	AF1
Number of Residues	4
Details	binding site for residue ZN Q 1001

Chain	Residue
Q	CYS286
Q	CYS289
Q	CYS294
Q	HIS297

---

site_id	AF2
Number of Residues	4
Details	binding site for residue ZN Q 1002

Chain	Residue
Q	CYS320
Q	GLN323
Q	CYS452
Q	CYS463

---

site_id	AF3
Number of Residues	4
Details	binding site for residue ZN Q 1003

Chain	Residue
Q	CYS530
Q	CYS543
Q	CYS549
Q	CYS553

---

site_id	AF4
Number of Residues	4
Details	binding site for residue ZN Q 1004

Chain	Residue
Q	CYS523
Q	HIS525
Q	CYS530
Q	CYS534

---

site_id	AF5
Number of Residues	4
Details	binding site for residue ZN Q 1005

Chain	Residue
Q	CYS523
Q	CYS536
Q	CYS543
Q	CYS547

---

site_id	AF6
Number of Residues	5
Details	binding site for residue ZN Q 1006

Chain	Residue
Q	CYS566
Q	CYS580
Q	CYS588
Q	CYS601
Q	ZN1008

---

site_id	AF7
Number of Residues	5
Details	binding site for residue ZN Q 1007

Chain	Residue
Q	CYS560
Q	CYS573
Q	CYS580
Q	CYS585
Q	ZN1008

---

site_id	AF8
Number of Residues	6
Details	binding site for residue ZN Q 1008

Chain	Residue
Q	CYS560
Q	CYS562
Q	CYS566
Q	CYS571
Q	ZN1006
Q	ZN1007

---

site_id	AF9
Number of Residues	15
Details	binding site for residue SAH Q 1009

Chain	Residue
Q	VAL621
Q	ALA622
Q	GLY623
Q	TRP624
Q	MET662
Q	CYS663
Q	SER664
Q	PHE665
Q	PHE686
Q	ASN688
Q	HIS689
Q	TYR726
Q	ALA733
Q	LEU734
Q	LYS735

---

site_id	AG1
Number of Residues	11
Details	binding site for Di-peptide ARG J 6 and M3L J 7

Chain	Residue
F	ASP136
F	GLU137
F	ASP140
G	TYR148
G	ILE363
G	TRP364
G	TYR365
G	ARG414
J	GLN5
J	PHE8
J	GLN10

---

site_id	AG2
Number of Residues	9
Details	binding site for Di-peptide M3L J 7 and PHE J 8

Chain	Residue
F	ASP136
F	GLU137
G	TYR148
G	ILE363
G	TRP364
G	TYR365
G	ARG414
J	ARG6
J	ALA9

---

site_id	AG3
Number of Residues	12
Details	binding site for Di-peptide ARG P 6 and M3L P 7

Chain	Residue
K	TYR133
K	ASP136
K	ASP140
L	TYR148
L	ILE363
L	TRP364
L	ARG414
P	GLN3
P	ALA4
P	GLN5
P	PHE8
P	GLN10

---

site_id	AG4
Number of Residues	10
Details	binding site for Di-peptide M3L P 7 and PHE P 8

Chain	Residue
K	TYR133
K	ASP136
K	GLU137
L	TYR148
L	ILE363
L	TRP364
L	ARG414
P	ARG6
P	ALA9
P	GLN10

---

site_id	AG5
Number of Residues	11
Details	binding site for Di-peptide ARG U 6 and M3L U 7

Chain	Residue
Q	TYR133
Q	ASP136
R	TYR148
R	ILE363
R	TRP364
R	TYR365
R	ARG414
U	ALA4
U	GLN5
U	PHE8
U	GLN10

---

site_id	AG6
Number of Residues	11
Details	binding site for Di-peptide M3L U 7 and PHE U 8

Chain	Residue
Q	TYR133
Q	ASP136
R	PHE97
R	TYR148
R	ILE363
R	TRP364
R	TYR365
R	ARG414
R	ASP430
U	ARG6
U	ALA9

---

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI

Chain	Residue	Details
B	LEU206-ILE220

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	460
Details	Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	116
Details	Region: {"description":"Interaction with EED","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKB/AKT1","evidences":[{"source":"PubMed","id":"16224021","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by CDK1 and CDK2","evidences":[{"source":"PubMed","id":"20935635","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"source":"PubMed","id":"24474760","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	172
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	172
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	160
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	164
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	148
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	160
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	132
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1440
Details	Region: {"description":"Interaction with EZH2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1176
Details	Region: {"description":"Required for interaction with the matrix protein MA of HIV-1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	12
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"20974918","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	304
Details	Region: {"description":"VEFS-box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	4
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	4
Details	Modified residue: {"description":"Citrulline","evidences":[{"source":"PubMed","id":"16567635","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	4
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5","evidences":[{"source":"PubMed","id":"10464286","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11856369","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15681610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15684425","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16457588","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---