5HYN
Structure of Human Polycomb Repressive Complex 2 (PRC2) with oncogenic histone H3K27M peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F, K, P (A, F, K, Q) | Histone-lysine N-methyltransferase EZH2 | polymer | 746 | 85492.3 | 4 | UniProt (Q15910) Pfam (PF11616) Pfam (PF18118) Pfam (PF21358) Pfam (PF18264) Pfam (PF00856) | Homo sapiens (Human) | ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6 |
| 2 | B, G, L, Q (B, G, L, R) | Polycomb protein EED | polymer | 367 | 42314.1 | 4 | UniProt (O75530) Pfam (PF00400) | Homo sapiens (Human) | hEED,WD protein associating with integrin cytoplasmic tails 1,WAIT-1 |
| 3 | C, H, M, R (C, H, M, S) | Polycomb protein SUZ12 | polymer | 129 | 15249.5 | 4 | UniProt (Q15022) Pfam (PF09733) | Homo sapiens (Human) | Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog |
| 4 | D, I, N, S (D, I, O, T) | H3K27M | polymer | 13 | 1234.4 | 4 | UniProt (by SIFTS) (P68431) | Homo sapiens | |
| 5 | E, J, O, T (E, J, P, U) | JARID2 K116me3 | polymer | 12 | 1505.7 | 4 | UniProt (by SIFTS) (Q92833) | Homo sapiens | |
| 6 | AA, AB, BA, BB, CB... (A, Q, F, K) | ZINC ION | non-polymer | 65.4 | 32 | Chemie (ZN) | |||
| 7 | CA, DB, LA, UA (A, Q, F, K) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 4 | Chemie (SAH) |
Sequence modifications
B, G, L, R: 77 - 441 (UniProt: O75530)
C, H, M, S: 558 - 685 (UniProt: Q15022)
| PDB | External Database | Details |
|---|---|---|
| Gly 75 | - | expression tag |
| Ser 76 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 557 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 20 |
| Total formula weight | 583184.5 | |
| Non-Polymers* | Number of molecules | 36 |
| Total formula weight | 3630.7 | |
| All* | Total formula weight | 586815.2 |
