5HYN
Structure of Human Polycomb Repressive Complex 2 (PRC2) with oncogenic histone H3K27M peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F, K, P (A, F, K, Q) | Histone-lysine N-methyltransferase EZH2 | polymer | 746 | 85492.3 | 4 | UniProt (Q15910) Pfam (PF11616) Pfam (PF18118) Pfam (PF21358) Pfam (PF18264) Pfam (PF00856) | Homo sapiens (Human) | ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6 |
| 2 | B, G, L, Q (B, G, L, R) | Polycomb protein EED | polymer | 367 | 42314.1 | 4 | UniProt (O75530) Pfam (PF00400) | Homo sapiens (Human) | hEED,WD protein associating with integrin cytoplasmic tails 1,WAIT-1 |
| 3 | C, H, M, R (C, H, M, S) | Polycomb protein SUZ12 | polymer | 129 | 15249.5 | 4 | UniProt (Q15022) Pfam (PF09733) | Homo sapiens (Human) | Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog |
| 4 | D, I, N, S (D, I, O, T) | H3K27M | polymer | 13 | 1234.4 | 4 | UniProt (by SIFTS) (P68431) | Homo sapiens | |
| 5 | E, J, O, T (E, J, P, U) | JARID2 K116me3 | polymer | 12 | 1505.7 | 4 | UniProt (by SIFTS) (Q92833) | Homo sapiens | |
| 6 | AA, AB, BA, BB, CB... (A, Q, F, K) | ZINC ION | non-polymer | 65.4 | 32 | Chemie (ZN) | |||
| 7 | CA, DB, LA, UA (A, Q, F, K) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 4 | Chemie (SAH) PubChem (16760024) PubChem (193) PubChem (25210495) PubChem (13792) PubChem (177678424) PubChem (44361184) PubChem (21125603) PubChem (46936206) PubChem (50989525) PubChem (25203782) PubChem (51380914) PubChem (52224398) PubChem (189149) PubChem (57544532) PubChem (439155) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (52224400) PubChem (5284331) PubChem (6419189) PubChem (118374891) PubChem (118560068) PubChem (71170554) PubChem (13231890) PubChem (164157219) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) |
Sequence modifications
B, G, L, R: 77 - 441 (UniProt: O75530)
C, H, M, S: 558 - 685 (UniProt: Q15022)
| PDB | External Database | Details |
|---|---|---|
| Gly 75 | - | expression tag |
| Ser 76 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 557 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 20 |
| Total formula weight | 583184.5 | |
| Non-Polymers* | Number of molecules | 36 |
| Total formula weight | 3630.7 | |
| All* | Total formula weight | 586815.2 |
