5HYJ

1E6 TCR in Complex with HLA-A02 carrying AQWGPDPAAA

Summary for 5HYJ

• Entry DOI: 10.2210/pdb5hyj/pdb
• Related: 5C07 5C08 5C09 5C0A 5C0B 5C0C 5C0D 5C0E 5C0F 5C0G 5C0H 5C0I 5C0J
• Descriptor: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ALA-GLN-TRP-GLY-PRO-ASP-PRO-ALA-ALA-ALA, ... (6 entities in total)
• Functional Keywords: immuno, hla-a02, 1e6-tcr, cross-reactivity, immune system
• Biological source: Homo sapiens (Human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P01892; Secreted : P61769
• Total number of polymer chains: 10
• Total formula weight: 189064.48

Authors

Rizkallah, P.J.,Bulek, A.M.,Cole, D.K.,Sewell, A.K. (deposition date: 2016-02-01, release date: 2016-05-04, Last modification date: 2024-01-10)

Primary citation

Stadinski, B.D.,Obst, R.,Huseby, E.S.
A "hotspot" for autoimmune T cells in type 1 diabetes.
J.Clin.Invest., 126:2040-2042, 2016

PubMed Abstract: The ability of a single T cell antigen receptor (TCR) to cross-react with multiple antigens allows the finite number of T cells within an organism to respond to the compendium of pathogen challenges faced during a lifetime. Effective immune surveillance, however, comes at a price. TCR cross-reactivity can allow molecular mimics to spuriously activate autoimmune T cells; it also underlies T cell rejection of organ transplants and drives graft-versus-host disease. In this issue of the JCI, Cole and colleagues provide insight into how an insulin-reactive T cell cross-reacts with pathogen-derived antigens by focusing on a limited portion of the peptides to provide a hotspot for binding. These findings dovetail with recent studies of alloreactive and autoimmune TCRs and suggest that the biochemical principles that govern conventional protein-protein interactions may allow the specificity and cross-reactivity profiles of T cells to be predicted.

PubMed: 27183386
DOI: 10.1172/JCI88165

Experimental method

X-RAY DIFFRACTION (3.06 Å)