5HX8
Jak1 complex with 4-[(4-aminocyclohexyl)amino]-3-(1H-benzimidazol-2-yl)-1H-pyridin-2-one
Summary for 5HX8
Entry DOI | 10.2210/pdb5hx8/pdb |
Descriptor | Tyrosine-protein kinase JAK1, 4-[(4-aminocyclohexyl)amino]-3-(1H-benzimidazol-2-yl)-1H-pyridin-2-one (3 entities in total) |
Functional Keywords | kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Endomembrane system; Peripheral membrane protein: P23458 |
Total number of polymer chains | 2 |
Total formula weight | 70139.97 |
Authors | Su, H.P. (deposition date: 2016-01-29, release date: 2016-03-16, Last modification date: 2017-11-22) |
Primary citation | Simov, V.,Deshmukh, S.V.,Dinsmore, C.J.,Elwood, F.,Fernandez, R.B.,Garcia, Y.,Gibeau, C.,Gunaydin, H.,Jung, J.,Katz, J.D.,Kraybill, B.,Lapointe, B.,Patel, S.B.,Siu, T.,Su, H.,Young, J.R. Structure-based design and development of (benz)imidazole pyridones as JAK1-selective kinase inhibitors. Bioorg.Med.Chem.Lett., 26:1803-1808, 2016 Cited by PubMed: 26927423DOI: 10.1016/j.bmcl.2016.02.035 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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