5HX8

Jak1 complex with 4-[(4-aminocyclohexyl)amino]-3-(1H-benzimidazol-2-yl)-1H-pyridin-2-one

Summary for 5HX8

Entry DOI	10.2210/pdb5hx8/pdb
Descriptor	Tyrosine-protein kinase JAK1, 4-[(4-aminocyclohexyl)amino]-3-(1H-benzimidazol-2-yl)-1H-pyridin-2-one (3 entities in total)
Functional Keywords	kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Endomembrane system; Peripheral membrane protein: P23458
Total number of polymer chains	2
Total formula weight	70139.97
Authors	Su, H.P. (deposition date: 2016-01-29, release date: 2016-03-16, Last modification date: 2017-11-22)
Primary citation	Simov, V.,Deshmukh, S.V.,Dinsmore, C.J.,Elwood, F.,Fernandez, R.B.,Garcia, Y.,Gibeau, C.,Gunaydin, H.,Jung, J.,Katz, J.D.,Kraybill, B.,Lapointe, B.,Patel, S.B.,Siu, T.,Su, H.,Young, J.R. Structure-based design and development of (benz)imidazole pyridones as JAK1-selective kinase inhibitors. Bioorg.Med.Chem.Lett., 26:1803-1808, 2016 Cited by PubMed: 26927423 DOI: 10.1016/j.bmcl.2016.02.035 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation