5HX8

Jak1 complex with 4-[(4-aminocyclohexyl)amino]-3-(1H-benzimidazol-2-yl)-1H-pyridin-2-one

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tyrosine-protein kinase JAK1	polymer	302	34746.6	2	UniProt (P23458) Pfam (PF07714)	Homo sapiens (Human)	Janus kinase 1,JAK-1
2	C, D (A, B)	4-[(4-aminocyclohexyl)amino]-3-(1H-benzimidazol-2-yl)-1H-pyridin-2-one	non-polymer		323.4	2	Chemie (66P)
3	E, F (A, B)	water	water		18.0	147	Chemie (HOH)

Sequence modifications

A, B: 854 - 1154 (UniProt: P23458)

PDB	External Database	Details
Gly 853	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	69493.2
Non-Polymers*	Number of molecules	2
	Total formula weight	646.8
All*	Total formula weight	70140.0

*Water molecules are not included.