5HVO

Structure of Aspergillus fumigatus trehalose-6-phosphate synthase B in complex with UDP and validoxylamine A

5HVO の概要

• エントリーDOI: 10.2210/pdb5hvo/pdb
• 関連するPDBエントリー: 5HUS 5HUT 5HUU 5HUV 5HVL 5HVM
• 分子名称: Alpha,alpha-trehalose-phosphate synthase (UDP-forming), URIDINE-5'-DIPHOSPHATE, (1S,2S,3R,6S)-4-(HYDROXYMETHYL)-6-{[(1S,2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL]AMINO}CYCLOHEX-4-ENE-1,2,3-TRIOL, ... (4 entities in total)
• 機能のキーワード: trehalose-6-phosphate synthase, transferase
• 由来する生物種: Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 218431.44

構造登録者

Miao, Y.,Brennan, R.G. (登録日: 2016-01-28, 公開日: 2017-05-03, 最終更新日: 2024-03-06)

• 主引用文献: Miao, Y.,Tenor, J.L.,Toffaletti, D.L.,Maskarinec, S.A.,Liu, J.,Lee, R.E.,Perfect, J.R.,Brennan, R.G.; Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.; MBio, 8:-, 2017; PubMed: 28743811; DOI: 10.1128/mBio.00643-17

実験手法

X-RAY DIFFRACTION (2.467 Å)