5HVO

Structure of Aspergillus fumigatus trehalose-6-phosphate synthase B in complex with UDP and validoxylamine A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0003825	molecular_function	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
A	0004805	molecular_function	trehalose-phosphatase activity
A	0005946	cellular_component	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
A	0005975	biological_process	carbohydrate metabolic process
A	0005992	biological_process	trehalose biosynthetic process
A	0016757	molecular_function	glycosyltransferase activity
A	0016758	molecular_function	hexosyltransferase activity
A	0034605	biological_process	cellular response to heat
A	0070413	biological_process	trehalose metabolism in response to stress
A	0102986	molecular_function	trehalose synthase activity
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0003825	molecular_function	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
B	0004805	molecular_function	trehalose-phosphatase activity
B	0005946	cellular_component	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
B	0005975	biological_process	carbohydrate metabolic process
B	0005992	biological_process	trehalose biosynthetic process
B	0016757	molecular_function	glycosyltransferase activity
B	0016758	molecular_function	hexosyltransferase activity
B	0034605	biological_process	cellular response to heat
B	0070413	biological_process	trehalose metabolism in response to stress
B	0102986	molecular_function	trehalose synthase activity
C	0000166	molecular_function	nucleotide binding
C	0003824	molecular_function	catalytic activity
C	0003825	molecular_function	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
C	0004805	molecular_function	trehalose-phosphatase activity
C	0005946	cellular_component	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
C	0005975	biological_process	carbohydrate metabolic process
C	0005992	biological_process	trehalose biosynthetic process
C	0016757	molecular_function	glycosyltransferase activity
C	0016758	molecular_function	hexosyltransferase activity
C	0034605	biological_process	cellular response to heat
C	0070413	biological_process	trehalose metabolism in response to stress
C	0102986	molecular_function	trehalose synthase activity
D	0000166	molecular_function	nucleotide binding
D	0003824	molecular_function	catalytic activity
D	0003825	molecular_function	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
D	0004805	molecular_function	trehalose-phosphatase activity
D	0005946	cellular_component	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
D	0005975	biological_process	carbohydrate metabolic process
D	0005992	biological_process	trehalose biosynthetic process
D	0016757	molecular_function	glycosyltransferase activity
D	0016758	molecular_function	hexosyltransferase activity
D	0034605	biological_process	cellular response to heat
D	0070413	biological_process	trehalose metabolism in response to stress
D	0102986	molecular_function	trehalose synthase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue UDP A 501

Chain	Residue
A	VAL285
A	VAL391
A	GLU394
A	VDM502
A	HOH623
A	HOH631
A	ARG287
A	LYS292
A	VAL322
A	SER363
A	VAL364
A	LEU369
A	ASN389
A	LEU390

---

site_id	AC2
Number of Residues	11
Details	binding site for residue VDM A 502

Chain	Residue
A	TRP105
A	ASP150
A	HIS152
A	HIS179
A	ASP386
A	GLY387
A	MET388
A	ASN389
A	UDP501
A	HOH617
A	HOH622

---

site_id	AC3
Number of Residues	13
Details	binding site for residue UDP B 501

Chain	Residue
B	VAL285
B	ARG287
B	LYS292
B	VAL322
B	SER363
B	VAL364
B	LEU369
B	LEU390
B	VAL391
B	GLU394
B	VDM502
B	HOH614
B	HOH633

---

site_id	AC4
Number of Residues	12
Details	binding site for residue VDM B 502

Chain	Residue
B	ASP150
B	HIS152
B	HIS179
B	ARG287
B	ARG325
B	ASP386
B	GLY387
B	MET388
B	ASN389
B	LEU390
B	UDP501
B	HOH613

---

site_id	AC5
Number of Residues	13
Details	binding site for residue UDP C 501

Chain	Residue
C	VAL285
C	ARG287
C	LYS292
C	VAL322
C	SER363
C	VAL364
C	LEU369
C	LEU390
C	VAL391
C	GLU394
C	VDM502
C	HOH609
C	HOH614

---

site_id	AC6
Number of Residues	12
Details	binding site for residue VDM C 502

Chain	Residue
C	ASP150
C	HIS152
C	HIS179
C	ILE249
C	ARG325
C	ASP386
C	GLY387
C	MET388
C	ASN389
C	LEU390
C	UDP501
C	HOH615

---

site_id	AC7
Number of Residues	11
Details	binding site for residue UDP D 501

Chain	Residue
D	ARG287
D	LYS292
D	VAL322
D	SER363
D	VAL364
D	LEU369
D	LEU390
D	VAL391
D	GLU394
D	VDM502
D	HOH622

---

site_id	AC8
Number of Residues	12
Details	binding site for residue VDM D 502

Chain	Residue
D	ASP150
D	HIS152
D	HIS179
D	ARG287
D	ARG325
D	ASP386
D	GLY387
D	MET388
D	ASN389
D	LEU390
D	UDP501
D	HOH619

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q92410

Chain	Residue	Details
A	TYR96
B	LYS292
B	ARG325
B	ASP386
C	TYR96
C	ASP150
C	ARG287
C	LYS292
C	ARG325
C	ASP386
D	TYR96
A	ASP150
D	ASP150
D	ARG287
D	LYS292
D	ARG325
D	ASP386
A	ARG287
A	LYS292
A	ARG325
A	ASP386
B	TYR96
B	ASP150
B	ARG287

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:28743811, ECO:0007744|PDB:5HVO

Chain	Residue	Details
A	SER363
A	LEU390
B	SER363
B	LEU390
C	SER363
C	LEU390
D	SER363
D	LEU390

---