5HVE

5-methyl-6-(3'-trifluromethoxyphenylthio)[2,3-d]pyrimidine 2,4-diamine

Summary for 5HVE

DescriptorDihydrofolate reductase, 5-methyl-6-{[3-(trifluoromethoxy)phenyl]sulfanyl}thieno[2,3-d]pyrimidine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
Functional Keywordsdihydrofolate reductase inhibitor complex with nadph, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationMitochondrion  P00374
Total number of polymer chains1
Total molecular weight22467.34
Authors
Cody, V. (deposition date: 2016-01-28, release date: 2017-02-01, Last modification date: 2017-09-27)
Primary citation
Cody, V.,Gangjee, A.
Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-(4'-methoxyphenythio)[2,3-d]pyrrolo-7-ethyl-2,4-diamines
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.46 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.227903.0%1.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution