5HUI

6-substituted pyrido[3,2-d]pyrimidine--6-4'-trifluoromethoxyphenyl)

Summary for 5HUI

• Entry DOI: 10.2210/pdb5hui/pdb
• Related: 5HVB
• Descriptor: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N~6~-methyl-N~6~-[4-(trifluoromethoxy)phenyl]pyrido[3,2-d]pyrimidine-2,4,6-triamine, ... (5 entities in total)
• Functional Keywords: dihydrofolate reductase inhibitor complex with nadph, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Mitochondrion : P00374
• Total number of polymer chains: 1
• Total formula weight: 22541.31

Authors

Cody, V. (deposition date: 2016-01-27, release date: 2017-02-01, Last modification date: 2023-09-27)

• Primary citation: Cody, V.,Gangjee, A.; Human dihydrofolate reductase ternary complex with a series of 6-substituted pyrido[3,2]pyrimidine-6-(4'-trifluoromethoxypheny)-2,4-diamines; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.46 Å)