5HS6

Human 17beta-hydroxysteroid dehydrogenase type 14 in complex with Estrone

Summary for 5HS6

Entry DOI	10.2210/pdb5hs6/pdb
Related	5EN4
Descriptor	17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (9beta,13alpha)-3-hydroxyestra-1,3,5(10)-trien-17-one, ... (5 entities in total)
Functional Keywords	17bhsd14, estrone complex, oxidoreductase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : Q9BPX1
Total number of polymer chains	1
Total formula weight	29639.52
Authors	Bertoletti, N.,Marchais-Oberwinkler, S.,Heine, A.,Klebe, G. (deposition date: 2016-01-25, release date: 2016-07-13, Last modification date: 2024-01-10)
Primary citation	Bertoletti, N.,Braun, F.,Lepage, M.,Moller, G.,Adamski, J.,Heine, A.,Klebe, G.,Marchais-Oberwinkler, S. New Insights into Human 17 beta-Hydroxysteroid Dehydrogenase Type 14: First Crystal Structures in Complex with a Steroidal Ligand and with a Potent Nonsteroidal Inhibitor. J.Med.Chem., 59:6961-6967, 2016 Cited by PubMed: 27362750 DOI: 10.1021/acs.jmedchem.6b00293 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.02 Å)

Structure validation