5HS3

Human thymidylate synthase complexed with dUMP and 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol

5HS3 の概要

• エントリーDOI: 10.2210/pdb5hs3/pdb
• 分子名称: Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol, ... (4 entities in total)
• 機能のキーワード: nhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 201704.37

構造登録者

Chen, D.,Almqvist, H.,Axelsson, H.,Jafari, R.,Mateus, A.,Haraldsson, M.,Larsson, A.,Artursson, P.,Molina, D.M.,Lundback, T.,Nordlund, P. (登録日: 2016-01-25, 公開日: 2016-02-24, 最終更新日: 2023-11-08)

• 主引用文献: Almqvist, H.,Axelsson, H.,Jafari, R.,Chen, D.,Mateus, A.,Haraldsson, M.,Larsson, A.,Molina, D.M.,Artursson, P.,Lundback, T.,Nordlund, P.; CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil; Nat Commun, 7:11040-11040, 2016; PubMed: 27010513; DOI: 10.1038/ncomms11040

実験手法

X-RAY DIFFRACTION (3.103 Å)