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5HQ8

Co-crystal Structure of human SMYD3 with a MEKK2 peptide at 2.13A

Summary for 5HQ8
Entry DOI10.2210/pdb5hq8/pdb
DescriptorHistone-lysine N-methyltransferase SMYD3, MEKK2 peptide, ZINC ION, ... (8 entities in total)
Functional Keywordssmyd3, methyltransferase, oncology, transferase
Biological sourceHomo sapiens (Human)
More
Cellular locationCytoplasm : Q9H7B4
Total number of polymer chains4
Total formula weight104231.26
Authors
Elkins, P.A.,Bonnette, W.G. (deposition date: 2016-01-21, release date: 2016-03-30, Last modification date: 2024-03-06)
Primary citationVan Aller, G.S.,Graves, A.P.,Elkins, P.A.,Bonnette, W.G.,McDevitt, P.J.,Zappacosta, F.,Annan, R.S.,Dean, T.W.,Su, D.S.,Carpenter, C.L.,Mohammad, H.P.,Kruger, R.G.
Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets.
Structure, 24:774-781, 2016
Cited by
PubMed: 27066749
DOI: 10.1016/j.str.2016.03.010
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.72 Å)
Structure validation

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