5HQ8
Co-crystal Structure of human SMYD3 with a MEKK2 peptide at 2.13A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone-lysine N-methyltransferase SMYD3 | polymer | 432 | 49542.5 | 2 | UniProt (Q9H7B4) Pfam (PF00856) Pfam (PF01753) | Homo sapiens (Human) | SET and MYND domain-containing protein 3,Zinc finger MYND domain-containing protein 1 |
| 2 | C, D (I, J) | MEKK2 peptide | polymer | 16 | 1735.9 | 2 | UniProt (by SIFTS) (Q9Y2U5) | Homo sapiens | |
| 3 | E, F, G, L, M... (A, B) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 4 | H, O (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | I, J, P, R, T... (A, B, I, J) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 6 | K, S (A, B) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) | |||
| 7 | Q (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 8 | V, W, X, Y (A, B, I, J) | water | water | 18.0 | 717 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 428 (UniProt: Q9H7B4)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Phe -1 | - | expression tag |
| Thr 0 | - | expression tag |
| Asn 13 | Lys 13 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 102556.9 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 1674.4 | |
| All* | Total formula weight | 104231.3 |
