5HPS

System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: WWP1 and UbV P1.1

Summary for 5HPS

• Entry DOI: 10.2210/pdb5hps/pdb
• Related: 5HPK 5HPL 5HPT
• Descriptor: WWP1 HECT, Ubiquitin variant P1.1 (3 entities in total)
• Functional Keywords: hect, e3 ligase, ubiquitin variant, ubv, ligase
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 54654.57

Authors

Wu, K.-P.,Mercredi, P.Y.,Schulman, B.A. (deposition date: 2016-01-20, release date: 2016-03-16, Last modification date: 2023-09-27)

• Primary citation: Zhang, W.,Wu, K.P.,Sartori, M.A.,Kamadurai, H.B.,Ordureau, A.,Jiang, C.,Mercredi, P.Y.,Murchie, R.,Hu, J.,Persaud, A.,Mukherjee, M.,Li, N.,Doye, A.,Walker, J.R.,Sheng, Y.,Hao, Z.,Li, Y.,Brown, K.R.,Lemichez, E.,Chen, J.,Tong, Y.,Harper, J.W.,Moffat, J.,Rotin, D.,Schulman, B.A.,Sidhu, S.S.; System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.; Mol.Cell, 62:121-136, 2016; PubMed: 26949039; DOI: 10.1016/j.molcel.2016.02.005

Experimental method

X-RAY DIFFRACTION (2.05 Å)