5HLW

Crystal structure of c-Met mutant Y1230H in complex with compound 14

5HLW の概要

• エントリーDOI: 10.2210/pdb5hlw/pdb
• 分子名称: Hepatocyte growth factor receptor, CHLORIDE ION, 1-[2-(1-ethylpiperidin-4-yl)ethyl]-3-(6-{[6-(thiophen-2-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)urea, ... (4 entities in total)
• 機能のキーワード: transferase, transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34476.48

構造登録者

Vallee, F.,Pouzieux, S.,Marquette, J.P.,Houtmann, J. (登録日: 2016-01-15, 公開日: 2016-11-23, 最終更新日: 2024-05-08)

• 主引用文献: Ugolini, A.,Kenigsberg, M.,Rak, A.,Vallee, F.,Houtmann, J.,Lowinski, M.,Capdevila, C.,Khider, J.,Albert, E.,Martinet, N.,Nemecek, C.,Grapinet, S.,Bacque, E.,Roesner, M.,Delaisi, C.,Calvet, L.,Bonche, F.,Semiond, D.,Egile, C.,Goulaouic, H.,Schio, L.; Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844).; J.Med.Chem., 59:7066-7074, 2016; PubMed: 27355974; DOI: 10.1021/acs.jmedchem.6b00280

実験手法

X-RAY DIFFRACTION (1.97 Å)