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5HJP

Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease

Summary for 5HJP
Entry DOI10.2210/pdb5hjp/pdb
Related5HJS
DescriptorRetinoic acid receptor RXR-beta, Oxysterols receptor LXR-beta, 2-chloro-4-{1'-[(2R)-2-hydroxy-3-methyl-2-(trifluoromethyl)butanoyl]-4,4'-bipiperidin-1-yl}-N,N-dimethylbenzamide, ... (5 entities in total)
Functional Keywordsagonist, alzheimer's, signaling protein
Biological sourceHomo sapiens (Human)
More
Cellular locationNucleus: P28702 P55055
Total number of polymer chains4
Total formula weight117279.40
Authors
Parthasarathy, G.,Klein, D. (deposition date: 2016-01-13, release date: 2016-04-06, Last modification date: 2024-03-06)
Primary citationStachel, S.J.,Zerbinatti, C.,Rudd, M.T.,Cosden, M.,Suon, S.,Nanda, K.K.,Wessner, K.,DiMuzio, J.,Maxwell, J.,Wu, Z.,Uslaner, J.M.,Michener, M.S.,Szczerba, P.,Brnardic, E.,Rada, V.,Kim, Y.,Meissner, R.,Wuelfing, P.,Yuan, Y.,Ballard, J.,Holahan, M.,Klein, D.J.,Lu, J.,Fradera, X.,Parthasarathy, G.,Uebele, V.N.,Chen, Z.,Li, Y.,Li, J.,Cooke, A.J.,Bennett, D.J.,Bilodeau, M.T.,Renger, J.
Identification and in Vivo Evaluation of Liver X Receptor beta-Selective Agonists for the Potential Treatment of Alzheimer's Disease.
J.Med.Chem., 59:3489-3498, 2016
Cited by
PubMed: 27011007
DOI: 10.1021/acs.jmedchem.6b00176
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

217705

건을2024-03-27부터공개중

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