5HJP
Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease
Summary for 5HJP
Entry DOI | 10.2210/pdb5hjp/pdb |
Related | 5HJS |
Descriptor | Retinoic acid receptor RXR-beta, Oxysterols receptor LXR-beta, 2-chloro-4-{1'-[(2R)-2-hydroxy-3-methyl-2-(trifluoromethyl)butanoyl]-4,4'-bipiperidin-1-yl}-N,N-dimethylbenzamide, ... (5 entities in total) |
Functional Keywords | agonist, alzheimer's, signaling protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus: P28702 P55055 |
Total number of polymer chains | 4 |
Total formula weight | 117279.40 |
Authors | Parthasarathy, G.,Klein, D. (deposition date: 2016-01-13, release date: 2016-04-06, Last modification date: 2024-03-06) |
Primary citation | Stachel, S.J.,Zerbinatti, C.,Rudd, M.T.,Cosden, M.,Suon, S.,Nanda, K.K.,Wessner, K.,DiMuzio, J.,Maxwell, J.,Wu, Z.,Uslaner, J.M.,Michener, M.S.,Szczerba, P.,Brnardic, E.,Rada, V.,Kim, Y.,Meissner, R.,Wuelfing, P.,Yuan, Y.,Ballard, J.,Holahan, M.,Klein, D.J.,Lu, J.,Fradera, X.,Parthasarathy, G.,Uebele, V.N.,Chen, Z.,Li, Y.,Li, J.,Cooke, A.J.,Bennett, D.J.,Bilodeau, M.T.,Renger, J. Identification and in Vivo Evaluation of Liver X Receptor beta-Selective Agonists for the Potential Treatment of Alzheimer's Disease. J.Med.Chem., 59:3489-3498, 2016 Cited by PubMed: 27011007DOI: 10.1021/acs.jmedchem.6b00176 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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