5HJP
Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Retinoic acid receptor RXR-beta | polymer | 254 | 28047.3 | 2 | UniProt (P28702) Pfam (PF00104) | Homo sapiens (Human) | Nuclear receptor subfamily 2 group B member 2,Retinoid X receptor beta |
| 2 | B, D (B, D) | Oxysterols receptor LXR-beta | polymer | 264 | 29968.3 | 2 | UniProt (P55055) Pfam (PF00104) | Homo sapiens (Human) | Liver X receptor beta,Nuclear receptor NER,Nuclear receptor subfamily 1 group H member 2,Ubiquitously-expressed nuclear receptor |
| 3 | E, H (B, D) | 2-chloro-4-{1'-[(2R)-2-hydroxy-3-methyl-2-(trifluoromethyl)butanoyl]-4,4'-bipiperidin-1-yl}-N,N-dimethylbenzamide | non-polymer | 518.0 | 2 | Chemie (668) | |||
| 4 | F, G (B, C) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 5 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 46 | Chemie (HOH) |
Sequence modifications
A, C: 299 - 533 (UniProt: P28702)
B, D: 217 - 461 (UniProt: P55055)
| PDB | External Database | Details |
|---|---|---|
| Gly 534 | - | expression tag |
| Ser 535 | - | expression tag |
| Gly 536 | - | expression tag |
| Ser 537 | - | expression tag |
| Gly 538 | - | expression tag |
| Ser 539 | - | expression tag |
| His 540 | - | expression tag |
| Lys 541 | - | expression tag |
| Ile 542 | - | expression tag |
| Leu 543 | - | expression tag |
| His 544 | - | expression tag |
| Arg 545 | - | expression tag |
| Leu 546 | - | expression tag |
| Leu 547 | - | expression tag |
| Gln 548 | - | expression tag |
| Asp 549 | - | expression tag |
| Ser 550 | - | expression tag |
| Ser 551 | - | expression tag |
| Ser 552 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 259 | Gln 258 | engineered mutation |
| Gly 261 | Arg 260 | engineered mutation |
| Ser 262 | Asp 261 | engineered mutation |
| Ser 264 | Arg 263 | engineered mutation |
| Gly 462 | - | expression tag |
| Ser 463 | - | expression tag |
| Gly 464 | - | expression tag |
| Ser 465 | - | expression tag |
| Gly 466 | - | expression tag |
| Ser 467 | - | expression tag |
| His 468 | - | expression tag |
| Lys 469 | - | expression tag |
| Ile 470 | - | expression tag |
| Leu 471 | - | expression tag |
| His 472 | - | expression tag |
| Arg 473 | - | expression tag |
| Leu 474 | - | expression tag |
| Leu 475 | - | expression tag |
| Gln 476 | - | expression tag |
| Asp 477 | - | expression tag |
| Ser 478 | - | expression tag |
| Ser 479 | - | expression tag |
| Ser 480 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 116031.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1248.3 | |
| All* | Total formula weight | 117279.4 |
