5HJP

Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease

5HJP の概要

• エントリーDOI: 10.2210/pdb5hjp/pdb
• 関連するPDBエントリー: 5HJS
• 分子名称: Retinoic acid receptor RXR-beta, Oxysterols receptor LXR-beta, 2-chloro-4-{1'-[(2R)-2-hydroxy-3-methyl-2-(trifluoromethyl)butanoyl]-4,4'-bipiperidin-1-yl}-N,N-dimethylbenzamide, ... (5 entities in total)
• 機能のキーワード: agonist, alzheimer's, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus: P28702 P55055
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 117279.40

構造登録者

Parthasarathy, G.,Klein, D. (登録日: 2016-01-13, 公開日: 2016-04-06, 最終更新日: 2024-03-06)

• 主引用文献: Stachel, S.J.,Zerbinatti, C.,Rudd, M.T.,Cosden, M.,Suon, S.,Nanda, K.K.,Wessner, K.,DiMuzio, J.,Maxwell, J.,Wu, Z.,Uslaner, J.M.,Michener, M.S.,Szczerba, P.,Brnardic, E.,Rada, V.,Kim, Y.,Meissner, R.,Wuelfing, P.,Yuan, Y.,Ballard, J.,Holahan, M.,Klein, D.J.,Lu, J.,Fradera, X.,Parthasarathy, G.,Uebele, V.N.,Chen, Z.,Li, Y.,Li, J.,Cooke, A.J.,Bennett, D.J.,Bilodeau, M.T.,Renger, J.; Identification and in Vivo Evaluation of Liver X Receptor beta-Selective Agonists for the Potential Treatment of Alzheimer's Disease.; J.Med.Chem., 59:3489-3498, 2016; PubMed: 27011007; DOI: 10.1021/acs.jmedchem.6b00176

実験手法

X-RAY DIFFRACTION (2.6 Å)