5HJO
Murine endoplasmic reticulum alpha-glucosidase II with bound substrate analogue
Summary for 5HJO
Entry DOI | 10.2210/pdb5hjo/pdb |
Descriptor | Neutral alpha-glucosidase AB, Glucosidase 2 subunit beta, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total) |
Functional Keywords | enzyme glycosyl hydrolase, gh31, quality control exoglycosidase, hydrolase |
Biological source | Mus musculus (Mouse) More |
Cellular location | Endoplasmic reticulum : Q8BHN3 O08795 |
Total number of polymer chains | 4 |
Total formula weight | 217311.79 |
Authors | Caputo, A.T.,Roversi, P.,Alonzi, D.S.,Kiappes, J.L.,Zitzmann, N. (deposition date: 2016-01-13, release date: 2016-07-27, Last modification date: 2020-07-29) |
Primary citation | Caputo, A.T.,Alonzi, D.S.,Marti, L.,Reca, I.B.,Kiappes, J.L.,Struwe, W.B.,Cross, A.,Basu, S.,Lowe, E.D.,Darlot, B.,Santino, A.,Roversi, P.,Zitzmann, N. Structures of mammalian ER alpha-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals. Proc.Natl.Acad.Sci.USA, 113:E4630-E4638, 2016 Cited by PubMed: 27462106DOI: 10.1073/pnas.1604463113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.29 Å) |
Structure validation
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