5HJ3

Crystal structure of host-primed Ebola virus GP, GPcl.

5HJ3 の概要

• エントリーDOI: 10.2210/pdb5hj3/pdb
• 分子名称: Envelope glycoprotein, KZ52 Antibody Fragment, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: ebola virus, eov, ebolavirus, gp, glycoprotein, gpcl, cleaved, primed, proteolytically, receptor binding pocket, crest, trough, mr72, kz52, broadly neutralizing, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Ebola virus sp.; 詳細
• 細胞内の位置: GP2: Virion membrane ; Single-pass type I membrane protein . GP1: Virion membrane ; Peripheral membrane protein. GP2-delta: Secreted : Q05320 P87666
• タンパク質・核酸の鎖数: 16
• 化学式量合計: 336368.72

構造登録者

Bornholdt, Z.A.,Fusco, M.L.,Saphire, E.O. (登録日: 2016-01-12, 公開日: 2016-03-09, 最終更新日: 2020-07-29)

• 主引用文献: Bornholdt, Z.A.,Ndungo, E.,Fusco, M.L.,Bale, S.,Flyak, A.I.,Crowe, J.E.,Chandran, K.,Saphire, E.O.; Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies.; Mbio, 7:e02154-e02115, 2016; PubMed: 26908579; DOI: 10.1128/mBio.02154-15

実験手法

X-RAY DIFFRACTION (3.3 Å)