5HGI
Crystal structure of apo human IRE1 alpha
Summary for 5HGI
Entry DOI | 10.2210/pdb5hgi/pdb |
Descriptor | Serine/threonine-protein kinase/endoribonuclease IRE1, CESIUM ION, SODIUM ION, ... (8 entities in total) |
Functional Keywords | ser/thr protein kinase, rnase, transferase-oxidoreductase complex, transferase/oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Endoplasmic reticulum membrane ; Single-pass type I membrane protein : O75460 |
Total number of polymer chains | 1 |
Total formula weight | 50620.56 |
Authors | Feldman, H.C.,Tong, M.,Wang, L.,Meza-Acevedo, R.,Gobillot, T.A.,Gliedt, J.M.,Hari, S.B.,Mitra, A.K.,Backes, B.J.,Papa, F.R.,Seeliger, M.A.,Maly, D.J. (deposition date: 2016-01-08, release date: 2016-06-08, Last modification date: 2023-09-27) |
Primary citation | Feldman, H.C.,Tong, M.,Wang, L.,Meza-Acevedo, R.,Gobillot, T.A.,Lebedev, I.,Gliedt, M.J.,Hari, S.B.,Mitra, A.K.,Backes, B.J.,Papa, F.R.,Seeliger, M.A.,Maly, D.J. Structural and Functional Analysis of the Allosteric Inhibition of IRE1 alpha with ATP-Competitive Ligands. Acs Chem.Biol., 11:2195-2205, 2016 Cited by PubMed: 27227314DOI: 10.1021/acschembio.5b00940 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.584 Å) |
Structure validation
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