5HGG

Crystal structure of uPA in complex with a camelid-derived antibody fragment

5HGG の概要

• エントリーDOI: 10.2210/pdb5hgg/pdb
• 分子名称: Urokinase-type plasminogen activator, Camelid Derived Antibody Fragment, Nb4, GLYCEROL, ... (7 entities in total)
• 機能のキーワード: upa, nanobody, serine protease, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Secreted: P00749
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 84538.65

構造登録者

Yung, K.W.Y.,Kromann-Hansen, T.,Andreasen, P.A.,Ngo, J.C.K. (登録日: 2016-01-08, 公開日: 2016-06-01, 最終更新日: 2016-08-10)

• 主引用文献: Kromann-Hansen, T.,Oldenburg, E.,Yung, K.W.,Ghassabeh, G.H.,Muyldermans, S.,Declerck, P.J.,Huang, M.,Andreasen, P.A.,Ngo, J.C.; A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior; J.Biol.Chem., 291:15156-15168, 2016; PubMed: 27226628; DOI: 10.1074/jbc.M116.732503

実験手法

X-RAY DIFFRACTION (1.97 Å)