5HFU

Crystal Structure of Human Hexokinase 2 with cmpd 27, a 2-amido-6-benzenesulfonamide glucosamine

5HFU の概要

• エントリーDOI: 10.2210/pdb5hfu/pdb
• 関連するPDBエントリー: 5HEX
• 分子名称: Hexokinase-2, ~{N}-[(2~{S},3~{R},4~{R},5~{S},6~{R})-6-[[(4-cyanophenyl)sulfonylamino]methyl]-2,4,5-tris(oxidanyl)oxan-3-yl]-3-phenyl-benzamide (3 entities in total)
• 機能のキーワード: metabolism, inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Mitochondrion outer membrane : P52789
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 208299.25

構造登録者

Campobasso, N.,Zhao, B.,Smallwood, A. (登録日: 2016-01-07, 公開日: 2016-03-30, 最終更新日: 2024-03-06)

• 主引用文献: Lin, H.,Zeng, J.,Xie, R.,Schulz, M.J.,Tedesco, R.,Qu, J.,Erhard, K.F.,Mack, J.F.,Raha, K.,Rendina, A.R.,Szewczuk, L.M.,Kratz, P.M.,Jurewicz, A.J.,Cecconie, T.,Martens, S.,McDevitt, P.J.,Martin, J.D.,Chen, S.B.,Jiang, Y.,Nickels, L.,Schwartz, B.J.,Smallwood, A.,Zhao, B.,Campobasso, N.,Qian, Y.,Briand, J.,Rominger, C.M.,Oleykowski, C.,Hardwicke, M.A.,Luengo, J.I.; Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors.; Acs Med.Chem.Lett., 7:217-222, 2016; PubMed: 26985301; DOI: 10.1021/acsmedchemlett.5b00214

実験手法

X-RAY DIFFRACTION (2.923 Å)