5HCY

EGFR kinase domain mutant "TMLR" with 3-carboxamide azaindole compound 13

Summary for 5HCY

• Entry DOI: 10.2210/pdb5hcy/pdb
• Related: 5HCX 5HCZ
• Descriptor: Epidermal growth factor receptor, SULFATE ION, 6-[[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]amino]-~{N}-(oxan-4-yl)-1-propan-2-yl-pyrrolo[3,2-c]pyridine-3-carboxamide, ... (4 entities in total)
• Functional Keywords: protein kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• Total number of polymer chains: 1
• Total formula weight: 38196.09

Authors

Eigenbrot, C.,Yu, C. (deposition date: 2016-01-04, release date: 2016-09-07, Last modification date: 2024-03-06)

• Primary citation: Chan, B.K.,Hanan, E.J.,Bowman, K.K.,Bryan, M.C.,Burdick, D.,Chan, E.,Chen, Y.,Clausen, S.,Dela Vega, T.,Dotson, J.,Eigenbrot, C.,Elliott, R.L.,Heald, R.A.,Jackson, P.S.,Knight, J.D.,La, H.,Lainchbury, M.D.,Malek, S.,Purkey, H.E.,Schaefer, G.,Schmidt, S.,Seward, E.M.,Sideris, S.,Shao, L.,Wang, S.,Yeap, S.K.,Yen, I.,Yu, C.,Heffron, T.P.; Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor.; J.Med.Chem., 59:9080-9093, 2016; PubMed: 27564586; DOI: 10.1021/acs.jmedchem.6b00995

Experimental method

X-RAY DIFFRACTION (2.46 Å)