5HCY
EGFR kinase domain mutant "TMLR" with 3-carboxamide azaindole compound 13
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Epidermal growth factor receptor | polymer | 331 | 37549.4 | 1 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | A | 6-[[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]amino]-~{N}-(oxan-4-yl)-1-propan-2-yl-pyrrolo[3,2-c]pyridine-3-carboxamide | non-polymer | 550.6 | 1 | Chemie (60D) | |||
| 4 | water | water | 18.0 | 90 | Chemie (HOH) |
Sequence modifications
A: 696 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 694 | - | expression tag |
| Ser 695 | - | expression tag |
| Met 790 | Thr 790 | engineered mutation |
| Arg 858 | Leu 858 | engineered mutation |
| Ala 865 | Glu 865 | engineered mutation |
| Ala 866 | Glu 866 | engineered mutation |
| Ala 867 | Lys 867 | engineered mutation |
| Asn 1023 | - | expression tag |
| Ser 1024 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37549.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 646.7 | |
| All* | Total formula weight | 38196.1 |
