5H8B
Crystal structure of CK2 with compound 2
Summary for 5H8B
Entry DOI | 10.2210/pdb5h8b/pdb |
Related | 5H8E 5H8G |
Descriptor | Casein kinase II subunit alpha, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | kinase, inhibitor, ck2, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P68400 |
Total number of polymer chains | 2 |
Total formula weight | 83060.11 |
Authors | Ferguson, A.D. (deposition date: 2015-12-23, release date: 2016-02-10, Last modification date: 2023-09-27) |
Primary citation | Dowling, J.E.,Alimzhanov, M.,Bao, L.,Chuaqui, C.,Denz, C.R.,Jenkins, E.,Larsen, N.A.,Lyne, P.D.,Pontz, T.,Ye, Q.,Holdgate, G.A.,Snow, L.,O'Connell, N.,Ferguson, A.D. Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo. Acs Med.Chem.Lett., 7:300-305, 2016 Cited by PubMed: 26985319DOI: 10.1021/acsmedchemlett.5b00452 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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