5H1D

Crystal structure of C-terminal of RhoGDI2

Summary for 5H1D

Entry DOI	10.2210/pdb5h1d/pdb
Descriptor	Rho GDP-dissociation inhibitor 2 (2 entities in total)
Functional Keywords	signaling protein
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytosol : P52566
Total number of polymer chains	1
Total formula weight	16427.71
Authors	Liu, J. (deposition date: 2016-10-08, release date: 2016-10-26, Last modification date: 2023-11-08)
Primary citation	Liu, J.,Gao, J.,Li, F.,Ma, R.,Wei, Q.,Wang, A.,Wu, J.,Ruan, K. NMR characterization of weak interactions between RhoGDI2 and fragment screening hits. Biochim. Biophys. Acta, 1861:3061-3070, 2017 Cited by PubMed Abstract: The delineation of intrinsically weak interactions between novel targets and fragment screening hits has long limited the pace of hit-to-lead evolution. Rho guanine-nucleotide dissociation inhibitor 2 (RhoGDI2) is a novel target that lacks any chemical probes for the treatment of tumor metastasis. PubMed: 27721047 DOI: 10.1016/j.bbagen.2016.10.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.494 Å)

Structure validation