5GXO
Discovery of a compound that activates SIRT3 to deacetylate Manganese Superoxide Dismutase
Summary for 5GXO
Entry DOI | 10.2210/pdb5gxo/pdb |
Descriptor | Superoxide dismutase [Mn], mitochondrial, MANGANESE (II) ION (3 entities in total) |
Functional Keywords | superoxide dismutase acetylation, oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Mitochondrion matrix: P04179 |
Total number of polymer chains | 2 |
Total formula weight | 44658.16 |
Authors | |
Primary citation | Lu, J.,Zhang, H.,Chen, X.,Zou, Y.,Li, J.,Wang, L.,Wu, M.,Zang, J.,Yu, Y.,Zhuang, W.,Xia, Q.,Wang, J. A small molecule activator of SIRT3 promotes deacetylation and activation of manganese superoxide dismutase. Free Radic. Biol. Med., 112:287-297, 2017 Cited by PubMed: 28711502DOI: 10.1016/j.freeradbiomed.2017.07.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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