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5GWZ

The structure of Porcine epidemic diarrhea virus main protease in complex with an inhibitor

Summary for 5GWZ
Entry DOI10.2210/pdb5gwz/pdb
Related PRD IDPRD_002214
DescriptorPEDV main protease, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE (3 entities in total)
Functional Keywordspedv, main protease, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourcePorcine epidemic diarrhea virus CV777 (PEDV)
More
Total number of polymer chains4
Total formula weight67694.58
Authors
Wang, F.,Chen, C.,Yang, K.,Liu, X.,Liu, H.,Xu, Y.,Chen, X.,Liu, X.,Cai, Y.,Yang, H. (deposition date: 2016-09-14, release date: 2017-03-29, Last modification date: 2023-11-15)
Primary citationWang, F.,Chen, C.,Yang, K.,Xu, Y.,Liu, X.,Gao, F.,Liu, H.,Chen, X.,Zhao, Q.,Liu, X.,Cai, Y.,Yang, H.
Michael Acceptor-Based Peptidomimetic Inhibitor of Main Protease from Porcine Epidemic Diarrhea Virus
J. Med. Chem., 60:3212-3216, 2017
Cited by
PubMed: 28287727
DOI: 10.1021/acs.jmedchem.7b00103
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.444 Å)
Structure validation

217705

數據於2024-03-27公開中

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