5GTN

Human PPARgamma ligand binding dmain complexed with R35

Summary for 5GTN

Entry DOI	10.2210/pdb5gtn/pdb
Related	5GTO 5GTP
Descriptor	Peroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, 2-[4-[5-[(1~{R})-1-[(3,5-dimethoxyphenyl)carbamoyl-(phenylmethyl)carbamoyl]oxypropyl]-1,2-oxazol-3-yl]phenoxy]-2-methyl-propanoic acid, ... (4 entities in total)
Functional Keywords	ppargamma, agonist, transcription
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus: P37231
Total number of polymer chains	2
Total formula weight	34803.18
Authors	Jang, J.Y.,Suh, S.W. (deposition date: 2016-08-22, release date: 2017-07-05, Last modification date: 2023-11-08)
Primary citation	Jang, J.Y.,Koh, M.,Bae, H.,An, D.R.,Im, H.N.,Kim, H.S.,Yoon, J.Y.,Yoon, H.J.,Han, B.W.,Park, S.B.,Suh, S.W. Structural basis for differential activities of enantiomeric PPAR gamma agonists: Binding of S35 to the alternate site. Biochim. Biophys. Acta, 1865:674-681, 2017 Cited by PubMed: 28342850 DOI: 10.1016/j.bbapap.2017.03.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation