5GMQ

Structure of MERS-CoV RBD in complex with a fully human antibody MCA1

Summary for 5GMQ

• Entry DOI: 10.2210/pdb5gmq/pdb
• Descriptor: S protein, MCA1 heavy chain, MCA1 light chain, ... (6 entities in total)
• Functional Keywords: viral protein-immune system complex, viral protein/immune system
• Biological source: Middle East respiratory syndrome coronavirus; More
• Total number of polymer chains: 3
• Total formula weight: 73761.35

Authors

Chen, C.,Wang, J.M.,Zou, T.T.,Gao, X.P.,Cui, S.,Jin, Q. (deposition date: 2016-07-15, release date: 2017-05-31, Last modification date: 2024-11-20)

Primary citation

Chen, Z.,Bao, L.,Chen, C.,Zou, T.,Xue, Y.,Li, F.,Lv, Q.,Gu, S.,Gao, X.,Cui, S.,Wang, J.,Qin, C.,Jin, Q.
Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset.
J. Infect. Dis., 215:1807-1815, 2017

PubMed Abstract: Middle East respiratory syndrome coronavirus (MERS-CoV) infection in humans is highly lethal, with a fatality rate of 35%. New prophylactic and therapeutic strategies to combat human infections are urgently needed. We isolated a fully human neutralizing antibody, MCA1, from a human survivor. The antibody recognizes the receptor-binding domain of MERS-CoV S glycoprotein and interferes with the interaction between viral S and the human cellular receptor human dipeptidyl peptidase 4 (DPP4). To our knowledge, this study is the first to report a human neutralizing monoclonal antibody that completely inhibits MERS-CoV replication in common marmosets. Monotherapy with MCA1 represents a potential alternative treatment for human infections with MERS-CoV worthy of evaluation in clinical settings.

PubMed: 28472421
DOI: 10.1093/infdis/jix209

Experimental method

X-RAY DIFFRACTION (2.703 Å)