5GJE

Three-dimensional reconstruction of human LRP6 ectodomain complexed with Dkk1

5GJE の概要

• エントリーDOI: 10.2210/pdb5gje/pdb
• EMDBエントリー: 9501
• 分子名称: Low-density lipoprotein receptor-related protein 6, Dickkopf-related protein 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: wnt signaling, wnt co-receptor, lrp6, glycoprotein, antagonist, dkk1, conformational change, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 151666.37

構造登録者

Matoba, K.,Mihara, E.,Tamura-Kawakami, K.,Hirai, H.,Thompson, S.,Iwasaki, K.,Takagi, J. (登録日: 2016-06-29, 公開日: 2017-01-18, 最終更新日: 2020-07-29)

• 主引用文献: Matoba, K.,Mihara, E.,Tamura-Kawakami, K.,Miyazaki, N.,Maeda, S.,Hirai, H.,Thompson, S.,Iwasaki, K.,Takagi, J.; Conformational Freedom of the LRP6 Ectodomain Is Regulated by N-glycosylation and the Binding of the Wnt Antagonist Dkk1; Cell Rep, 18:32-40, 2017; PubMed: 28052259; DOI: 10.1016/j.celrep.2016.12.017

実験手法

ELECTRON MICROSCOPY (21 Å)