5GIT

BTB domain of KEAP1 in complex with XX3

Summary for 5GIT

• Entry DOI: 10.2210/pdb5git/pdb
• Descriptor: Kelch-like ECH-associated protein 1, [(3aS,5R,5aS,6S,8S,8aS,9S,9aR)-9-acetyloxy-8-hydroxy-5,8a-dimethyl-1-methylidene-2-oxo-4,5,5a,6,7,8,9,9a-octahydro-3aH-azuleno[6,5-b]furan-6-yl] acetate (3 entities in total)
• Functional Keywords: signaling protein, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15660.06

Authors

Zhu, L.L.,Li, H.L.,Wu, F.S.,Xiong, R. (deposition date: 2016-06-25, release date: 2017-06-28, Last modification date: 2025-04-09)

Primary citation

Wu, G.Z.,Zhu, L.L.,Yuan, X.,Chen, H.,Xiong, R.,Zhang, S.D.,Cheng, H.,Shen, Y.H.,An, H.Z.,Li, T.J.,Li, H.L.,Zhang, W.D.
Britanin Ameliorates Cerebral Ischemia-Reperfusion Injury by Inducing the Nrf2 Protective Pathway.
Antioxid. Redox Signal., 27:754-768, 2017

PubMed Abstract: Oxidative stress is considered the major cause of tissue injury after cerebral ischemia. The nuclear factor erythroid 2-related factor 2 (Nrf2) pathway is one of the most important defensive mechanisms against oxidative stresses and has been confirmed as a target for stroke treatment. Thus, we desired to find new Nrf2 activators and test their neuronal protective activity both in vivo and in vitro.

PubMed: 28186440
DOI: 10.1089/ars.2016.6885

Experimental method

X-RAY DIFFRACTION (2.19 Å)