5G2V

Structure of BT4656 in complex with its substrate D-Glucosamine-2-N, 6-O-disulfate.

Summary for 5G2V

• Entry DOI: 10.2210/pdb5g2v/pdb
• Related: 5G2T 5G2U
• Descriptor: N-ACETYLGLUCOSAMINE-6-SULFATASE, CALCIUM ION, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: hydrolase, glycosaminoglycan sulfatase
• Biological source: BACTEROIDES THETAIOTAOMICRON
• Total number of polymer chains: 1
• Total formula weight: 62782.21

Authors

Cartmell, A.,Lowe, E.C.,Basle, A.,Crouch, L.I.,Czjzek, M.,Turnbull, J.,Henrissat, B.,Terrapon, N.,Thomas, S.,Murray, H.,Firbank, S.J.,Bolam, D.N. (deposition date: 2016-04-14, release date: 2017-05-24, Last modification date: 2020-07-29)

• Primary citation: Cartmell, A.,Lowe, E.C.,Basle, A.,Firbank, S.J.,Ndeh, D.A.,Murray, H.,Terrapon, N.,Lombard, V.,Henrissat, B.,Turnbull, J.E.,Czjzek, M.,Gilbert, H.J.,Bolam, D.N.; How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans.; Proc. Natl. Acad. Sci. U.S.A., 114:7037-7042, 2017; PubMed: 28630303; DOI: 10.1073/pnas.1704367114

Experimental method

X-RAY DIFFRACTION (1.39 Å)