5G1X

Crystal structure of Aurora-A kinase in complex with N-Myc

Summary for 5G1X

Entry DOI	10.2210/pdb5g1x/pdb
Descriptor	AURORA KINASE A, N-MYC PROTO-ONCOGENE PROTEIN, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	transferase, aurora, aurora-a, kinase, n-myc, myc, neuroblastoma
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965 Nucleus: P04198
Total number of polymer chains	2
Total formula weight	40618.23
Authors	Richards, M.W.,Burgess, S.G.,Bayliss, R. (deposition date: 2016-03-31, release date: 2016-11-16, Last modification date: 2024-01-10)
Primary citation	Richards, M.,Burgess, S.,Poon, E.,Carstensen, A.,Eilers, M.,Chesler, L.,Bayliss, R. Structural Basis of N-Myc Binding by Aurora-A and its Destabilization by Kinase Inhibitors Proc.Natl.Acad.Sci.USA, 113:13726-, 2016 Cited by PubMed: 27837025 DOI: 10.1073/PNAS.1610626113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.72 Å)

Structure validation