5G1X
Crystal structure of Aurora-A kinase in complex with N-Myc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | AURORA KINASE A | polymer | 285 | 32964.6 | 1 | UniProt (O14965) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | AURORA 2, AURORA/IPL1-RELATED KINASE 1, ARK-1, AURORA-RELATED KINASE 1, HARK1, BREAST TUMOR-AMPLIFIED KINASE, SERINE/ THREONINE-PROTEIN KINASE 15, SERINE/THREONINE-PROTEIN KINASE 6, SERINE/ THREONINE-PROTEIN KINASE AURORA-A, AURORA-A |
| 2 | B (B) | N-MYC PROTO-ONCOGENE PROTEIN | polymer | 63 | 7177.8 | 1 | UniProt (P04198) | HOMO SAPIENS | CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 37, BHLHE37, N-MYC |
| 3 | C (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 4 | D, E (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 197 | Chemie (HOH) |
Sequence modifications
A: 122 - 403 (UniProt: O14965)
B: 28 - 89 (UniProt: P04198)
| PDB | External Database | Details |
|---|---|---|
| Gly 119 | - | expression tag |
| Ala 120 | - | expression tag |
| Met 121 | - | expression tag |
| Ala 290 | Cys 290 | engineered mutation |
| Ala 393 | Cys 393 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 27 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 40142.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 475.8 | |
| All* | Total formula weight | 40618.2 |
