5G03

An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C

Summary for 5G03

Entry DOI	10.2210/pdb5g03/pdb
Related	5G01 5G0B 5G0C
Descriptor	CARBONIC ANHYDRASE 2, ZINC ION, SULFATE ION, ... (5 entities in total)
Functional Keywords	lyase, natural product inhibitor, protein engineering, carbonic anhydrase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	29768.55
Authors	Mujumdar, P.,Supuran, C.T.,Peat, T.S.,Poulsen, S.A. (deposition date: 2016-03-16, release date: 2016-05-25, Last modification date: 2024-01-10)
Primary citation	Mujumdar, P.,Teruya, K.,Tonissen, K.F.,Vullo, D.,Supuran, C.T.,Peat, T.S.,Poulsen, S. An Unusual Natural Product Primary Sulfonamide: Synthesis, Carbonic Anhydrase Inhibition and Protein X-Ray Structures of Psammaplin C. J.Med.Chem., 59:5462-, 2016 Cited by PubMed: 27172398 DOI: 10.1021/ACS.JMEDCHEM.6B00443 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation