5G03
An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | CARBONIC ANHYDRASE 2 | polymer | 260 | 29226.9 | 1 | UniProt (P00918) Pfam (PF00194) In PDB | HOMO SAPIENS (HUMAN) | CARBONATE DEHYDRATASE II, CARBONIC ANHYDRASE C, CAC, CARBONIC ANHYDRASE II, CA-II |
| 2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | A | PSAMMAPLIN C | non-polymer | 380.2 | 1 | Chemie (OE2) | |||
| 5 | water | water | 18.0 | 261 | Chemie (HOH) |
Sequence modifications
A: 1 - 261 (UniProt: P00918)
| PDB | External Database | Details |
|---|---|---|
| Ser 65 | Ala 65 | engineered mutation |
| Gln 67 | Asn 67 | engineered mutation |
| Thr 69 | Glu 69 | engineered mutation |
| Leu 91 | Ile 91 | engineered mutation |
| Val 131 | Phe 130 | engineered mutation |
| Asp 132 | Gly 131 | engineered mutation |
| Leu 135 | Val 134 | engineered mutation |
| Glu 170 | Lys 169 | engineered mutation |
| Ala 204 | Leu 203 | engineered mutation |
| Gly 206 | Cys 205 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29226.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 541.7 | |
| All* | Total formula weight | 29768.5 |
