5FXS

IGFR-1R complex with a pyrimidine inhibitor.

5FXS の概要

• エントリーDOI: 10.2210/pdb5fxs/pdb
• 関連するPDBエントリー: 5FXQ 5FXR
• 分子名称: INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR, ACETATE ION, 2-[4-[4-[[(6Z)-5-chloranyl-6-pyrazolo[1,5-a]pyridin-3-ylidene-1H-pyrimidin-2-yl]amino]-3,5-dimethyl-pyrazol-1-yl]piperidin-1-yl]-N,N-dimethyl-ethanamide, ... (4 entities in total)
• 機能のキーワード: transferase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35851.46

構造登録者

Degorce, S.,Boyd, S.,Curwen, J.,Ducray, R.,Halsall, C.,Jones, C.,Lach, F.,Lenz, E.,Pass, M.,Pass, S.,Trigwell, C.,Norman, R.,Phillips, C. (登録日: 2016-03-02, 公開日: 2016-10-19, 最終更新日: 2024-05-08)

• 主引用文献: Degorce, S.L.,Boyd, S.,Curwen, J.O.,Ducray, R.,Halsall, C.T.,Jones, C.D.,Lach, F.,Lenz, E.M.,Pass, M.,Pass, S.,Trigwell, C.; Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2-(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor-1 Receptor (IGF-1R).; J. Med. Chem., 59:4859-4866, 2016; PubMed: 27078757; DOI: 10.1021/acs.jmedchem.6b00203

実験手法

X-RAY DIFFRACTION (1.9 Å)