5FWR

Breaking down the wall: mutation of the tyrosine gate of the universal Escherichia coli fimbrial adhesin FimH

Summary for 5FWR

• Entry DOI: 10.2210/pdb5fwr/pdb
• Related: 5FX3
• Descriptor: FimH, biphenyl-4-yl alpha-D-mannopyranoside (3 entities in total)
• Functional Keywords: cell adhesion, bacterial adhesin, type 1 fimbriae, urinary tract infection, variable immunoglobulin fold
• Biological source: Escherichia coli
• Total number of polymer chains: 8
• Total formula weight: 137993.41

Authors

Bouckaert, J. (deposition date: 2016-02-21, release date: 2016-11-30, Last modification date: 2024-01-10)

• Primary citation: Rabbani, S.,Krammer, E.M.,Roos, G.,Zalewski, A.,Preston, R.,Eid, S.,Zihlmann, P.,Prevost, M.,Lensink, M.F.,Thompson, A.,Ernst, B.,Bouckaert, J.; Mutation of Tyr137 of the universal Escherichia coli fimbrial adhesin FimH relaxes the tyrosine gate prior to mannose binding.; IUCrJ, 4:7-23, 2017; PubMed: 28250938; DOI: 10.1107/S2052252516016675

Experimental method

X-RAY DIFFRACTION (2.13 Å)