5FV7

Human Fen1 in complex with an N-hydroxyurea compound

5FV7 の概要

• エントリーDOI: 10.2210/pdb5fv7/pdb
• 分子名称: FLAP ENDONUCLEASE 1, MAGNESIUM ION, 1-[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione, ... (4 entities in total)
• 機能のキーワード: hydrolase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Isoform 1: Nucleus, nucleolus. Isoform FENMIT: Mitochondrion : P39748
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 80355.02

構造登録者

Exell, J.C.,Thompson, M.J.,Finger, L.D.,Shaw, S.K.,Abbott, W.M.,McWhirter, C.,Debreczeni, J.E.,Jones, C.D.,Nissink, J.W.M.,Ward, T.A.,Sioberg, C.W.L.,Molina, D.M.,Durant, S.T.,Grasby, J.A. (登録日: 2016-02-03, 公開日: 2016-08-17, 最終更新日: 2024-05-08)

• 主引用文献: Exell, J.C.,Thompson, M.J.,Finger, L.D.,Shaw, S.K.,Abbott, W.M.,Mcwhirter, C.,Debreczeni, J.E.,Jones, C.D.,Nissink, J.W.M.,Ward, T.A.,Sioberg, C.W.L.,Molina, D.M.,Durant, S.T.,Grasby, J.A.; Cellular Active N-Hydroxyurea Fen1 Inhibitors Block Substrate Entry to the Active Site; Nat.Chem.Biol., 12:815-, 2016; PubMed: 27526030; DOI: 10.1038/NCHEMBIO.2148

実験手法

X-RAY DIFFRACTION (2.84 Å)